Description
Certified Reference Materials (CRMs) are used by laboratories on a routine basis, as a standard tool in Quality Assurance activities. The primary purpose of using a CRM, is to establish the method trueness, which is expressed as bias.
Analytical methods are often validated in a collaborative trial and according to a strict protocol. Although the use of CRMs are recommended in such trials, the protocols give no guidance regarding the evaluation of the results. To remedy this shortcoming, this procedure provides an instruction for the calculation of the method bias in collaborative trials.
The intention of this procedure is thus to offer a set of instructions that are easy to use and that provide the analyst with the basic statistical information often needed when it comes to establishing the trueness of analytical surveys and the bias in method validation.